Measuring Blood Sugar with Light

Now a team of German researchers has devised a novel, non-invasive way to make monitoring easier. Using infrared laser light applied on top of the skin, they measure sugar levels in the fluid in and under skin cells to read GlycoMode blood sugar support sugar levels. They describe their method in the current edition of Review of Scientific Instruments, which is produced by AIP Publishing. Werner Mäntele, Ph.D. of Frankfurt's Institut für Biophysik, Johann Wolfgang Goethe-Universität. Their new optical approach uses photoacoustic spectroscopy (PAS) to measure glucose by its mid-infrared absorption of light. The data showing the skin cell glucose levels at one-hundredth of a millimeter beneath the skin is related to blood glucose levels, Mäntele said, but previous attempts to use PAS in this manner have been hampered by distortion related to changes of air pressure, temperature and humidity caused by the contact with living skin. To overcome these constraints, the team devised a design innovation of an open, windowless cell architecture. While it is still experimental and would have to be tested and approved by regulatory agencies before becoming commercially available, the team continues to refine it. The article, "Windowless ultrasound photoacoustic cell for in vivo mid-IR spectroscopy of human epidermis: Low interference by changes of air pressure, temperature, and humidity caused by skin contact opens the possibility for a non-invasive monitoring of glucose in the interstitial fluid," is authored by Miguel A. Pleitez, Tobias Lieblein, Alexander Bauer, Otto Hertzberg, Hermann von Lilienfeld-Toal, and Werner Mäntele. It appears in the journal Review of Scientific Instruments.

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